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Medea gene
''Medea'' is a gene from the fruitfly ''Drosophila melanogaster'' that was one of the first two Smad genes discovered. For both genes, the maternal effect lethality was the basis for selection of their names. Medea was named for the mythological Greek Medea, who killed her progeny fathered by Jason.
Both ''Medea'' and Mothers against dpp were identified in a genetic screen for maternal effect mutations that caused lethality of heterozygous Decapentaplegic progeny.〔Raftery L, Twombly V, Wharton K, Gelbart M. Genetic Screens to Identify Elements of the Decapentaplegic Signaling Pathway in Drosophila. Genetics 1995 139, 241-254〕 Because Decapentaplegic is a Bone morphogenetic protein in the Transforming growth factor beta superfamily, identification of the fly Smad genes provided a much needed clue to understand the signal transduction pathway for this diverse family of extracellular proteins. Humans, mice, and other vertebrates have a gene with the same function as ''Medea'', called SMAD4. An overview of the biology of ''Medea'' is found at The Interactive Fly http://www.sdbonline.org/fly/torstoll/medea1.htm, and the details of ''Medea'' genetics and molecular biology are curated on Flybase http://flybase.org/reports/FBgn0011655.html.
Another laboratory used Medea as an acronym to describe a synthetic gene causing Maternal effect dominant embryonic arrest. The formal genetic designation for Maternal effect dominant embryonic arrest is P, more details are in Flybase http://flybase.org/reports/FBtp0023218.html
==References==
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抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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